Villarreal 2 Zenit Saint Petersburg 1 (5-2 on agg)
Round of 16 2nd leg – Villarreal win 5-2 on aggregate
March 14, 2019
0
Slavia Prague 4 Sevilla 3 (AET 6-5 on agg)
Round of 16 2nd leg – Slavia Prague win 6-5 on aggregate AET
March 14, 2019
Salzburg 3 SSC Napoli 1 (3-4 on agg)
Round of 16 2nd leg – Napoli win 4-3 on aggregate
March 14, 2019
FC Krasnodar 1 Valencia 1 (2-3 on agg)
Round of 16 2nd leg – Valencia win 3-2 on aggregate
March 14, 2019
Dynamo Kiev 0 Chelsea 5 (0-8 on agg)
Round of 16 2nd leg – Chelsea win 8-0 on aggregate
March 14, 2019
SSC Napoli 3 Salzburg 0
Round of 16 1st leg
March 7, 2019
Chelsea 3 Dynamo Kiev 0
Round of 16 1st leg
March 7, 2019
Valencia 2 FC Krasnodar 1
Round of 16 1st leg
March 7, 2019
Rennes 3 Arsenal 1
Round of 16 1st leg
March 7, 2019
Eintracht Frankfurt 0 Inter 0
Round of 16 1st leg
March 7, 2019