Villarreal 1 Sporting CP 1 (2-1 on agg)
Round of 32 2nd leg – Villarreal win 2-1 on aggregate
February 21, 2019
0
Eintracht Frankfurt 4 Shakhtar Donetsk 1 (6-3 on agg)
Round of 32 2nd leg – Eintracht Frankfurt win 6-3 on aggregate
February 21, 2019
SSC Napoli 2 FC Zurich 0 (5-1 on agg)
Round of 32 2nd leg – Napoli win 5-1 on aggregate
February 21, 2019
Sevilla 2 Lazio 0 (3-0 on agg)
Round of 32 2nd leg – Sevilla win 3-0 on aggregate
February 20, 2019
FC Zurich 1 SSC Napoli 3
Round of 32 1st leg
February 14, 2019
Sporting CP 0 Villarreal 1
Round of 32 1st leg
February 14, 2019
Lazio 0 Sevilla 1
Round of 32 1st leg
February 14, 2019
Galatasaray 1 Benfica 2
Round of 32 1st leg
February 14, 2019
Rapid Vienna 0 Inter 1
Round of 32 1st leg
February 14, 2019
Fenerbahce 1 Zenit Saint Petersburg 0
Round of 32 1st leg
February 12, 2019